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Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.
S3, EP11 "Speck of Evidence"
A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.
S6, EP6 "Fire Dot Com"
A mother puts her hope in the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.
S2, EP7 "Fatal Fungus"
When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.
S1, EP1 "The Disappearance of Helle Crafts"
The investigation into the disappearance of flight attendant Helle Crafts leads to the murder conviction of her pilot husband.
S14, EP21 "Expert Witness"
A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.
S14, EP20 "Funeral Services"
Police discover a mask near the crime scene and hope that it leads to the killer of a funeral director.
S14, EP19 "Skeleton Key"
A woman goes missing for a month with the only clues being a set of keys, a fingerprint and a code.
S14, EP17 "Seeing Red"
A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.