
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A serial killer in Tampa, Fla., taunts police by strangling prostitutes and leaving their bodies in plain sight, but tire marks and fibers lead to the culprit.
A rare gun and a victim's beloved dog help investigators trying to solve a multi-year-long murder case where most of the witnesses were admitted drug users.
Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.
An 11-year-old girl is sexually assaulted and shot twice at close range.