
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.

Investigators build a makeshift tent around a woman's body and use superglue fumes to lift the killer's palm print from the victim's skin.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.