
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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Florida authorities rely on DNA evidence to try to nail the killer of a woman who was abducted from her late-night job at a convenience store, raped and strangled.
A wildfire in a secluded parking lot leads police to discover a dreadful homicide, with the suspect's image caught by security cameras.
A killer leaves equally incriminating evidence at the scene when he meticulously wipes away his fingerprint and shoe impressions.
Police don't have a basis for comparison to match shoe impressions, blood drops and DNA evidence from a murder scene.