
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

A woman gets shot in her driveway; she may have been the victim of a co-worker half her age that she had recently rejected.

A pair of tennis shoes are found near a victim who had been stabbed on the beach, less than ten yards from her hotel.

San Diego police investigate the murder of a missing person whose hands turn up in a dumpster; an anonymous letter, containing details only the killer would know, offers clues to solving the case.