
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A bite mark is all the evidence needed to convict a suspect who was robbing tourists in Florida.
Technology able to analyze human bite-marks yields information on a woman's death.
A death in Pennsylvania is strikingly similar to one in North Carolina.
Time of death becomes pivotal when a pregnant woman is found murdered in her air-conditioned bedroom.