
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A DNA dragnet catches a killer eight years after the kidnapping, rape and murder of a college coed in Oklahoma.

Tara Munsey went missing after a work shift at a Virginia restaurant, and it is unknown if she ran away or if she was the victim of foul play.

Volunteers and police spend weeks searching for a missing girl. A psychic later leads them to a field where the body was found.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpses are found floating in Tampa Bay with a handwritten note by one of the victims; putting it on five billboards helps them find the killer.