
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

While investigating the case of a Colorado hunter shot three times and killed, police suspect two murder weapons, and two killers, but forensic evidence points them closer to home.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.