
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

A serial arsonist burns thousands of California homes and businesses.

A handsome young doctor's fiancée experiences severe illness after revealing that she is pregnant, and launches her own investigation to determine if the doctor is somehow responsible.