
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Eight years after a man confessed to the murder of a young woman, another man claims that he committed the crime, and investigators must use forensic evidence to determine the true killer.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

When detectives find a mismatched button in relation to a woman's death, they know they can follow the clue back to the killer.

When a young boy has serious respiratory problems and his father shows signs of early Alzheimer's disease, a chance encounter with a stranger kicks off an investigation into the cause.