
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

Investigators use obscure evidence to find the person responsible for killing justice officials with mail bombs in the South.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.