
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.

When a 12-year-old was found dead in her home, police were left clueless until a string of burglaries months later. A trail of stolen goods may help solve a murder.

When a sexual predator murders two young boys in Nebraska, an obscure style of rope and forensic analysis lead to his arrest and conviction.

Experts debate whether an apparent heart attack victim died from natural causes or alleged poisoning by his girlfriend.