
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Investigators search the world of high rollers and offshore betting to solve the first triple homicide in Verona, Wisc.

When a Pennsylvania man checks into a hospital for leg pain and later dies of thallium poisoning, police investigate his wife and find her in the process of collecting an insurance payment for her previous husband's death.

Police search every apartment building in town when the body of a young girl found on an isolated farm holds a set of keys but no ID.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.