
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A young college student is found dead in her apartment and the autopsy rules the death a homicide by an unknown male suspect.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

The killer removed the computer that links him to the murder of a woman and her soon-to-be ex-husband that he had met online.

Missouri police are thrust into a bizarre web of homeless drifters and cattle auctions when they are called to retrieve a dead body.