
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a policeman's home burns to the ground, he later arrests a man who confesses to arson, but the confession seems dubious.

A woman identifies her husband as her attacker, but questions arise 16 years later regarding her recollections.

A mother and her two young daughters are found brutally murdered and sexually violated; the crime scene has no shortage of evidence, but investigators cannot find a conclusive link to their prime suspect.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.