
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.
In a groundbreaking case using animal DNA, investigators use forensic testing on a cat to help them solve the case of a woman who vanished from her home on Prince Edward Island.
A look into the 1984 Oregon food poisonings, where detectives track down the outbreak to a cult which aims to use germ warfare to take down the government.
A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened, and the truth is stranger than fiction.