
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A new life-insurance policy sparks suspicions of murder when a Nova Scotia schoolteacher's body is found at the bottom of her basement stairs.

In a wealthy area of Philadelphia, police are called to the scene of what seems like a regular accidental drowning; the investigation begins to focus on one person who has many reasons to want the victim dead.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

Two women are murdered in the same town and police fear a serial killer is on the loose, further investigation finds that they were both close to the same man.