
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

An ammunition box and fluorescent fibers reveal the betrayal that led to the murder of a millionaire's family.

A young girl is found dead, the victim of an apparent sex killer; there are few clues to the killer's identity, but authorities are intrigued by unusual orange fibers embedded in clothing found near the victim.

The 1960 kidnapping and murder of brewery heir Adolph Coors III leads to one of the most intense manhunts in U.S. history.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.