
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The robbery and brutal murder of an elderly couple goes unsolved for 10 years; a forensic scientist makes history when he solves the crime.

A man is charged with the murder of a wrestling champion; six years later, a forensic animator testifies on his behalf.

Fifteen years after a man disappears, using a metal detector, police find evidence which proves what had happened.

The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.