
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.
Forensic scientists provide authorities with evidence that a death deemed accidental 20 years ago was actually murder.
A man is arrested and convicted for a series of sexual assaults in Indiana; years later, forensic developments reveal new facts about the case.
Detectives learn that a genetic disorder caused the deaths of a woman's children, resulting in an overturned conviction.