
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A man tells police he shot an intruder who murdered his wife; forensic evidence leads police to re-examine the man's motives.

The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.

The 1992 hit-and-run death of 6-year-old Nicole Rae Walker leads to a groundbreaking trial as experts submit a video reconstruction of the incident, implicating a drunk driver and demonstrating the viability of video testimony.

A homicide detective claims his wife accidentally shot herself in the head, but the evidence indicates otherwise.