
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a young doctor is accused of sedating and sexually assaulting two of his female patients, DNA tests show him to be innocent, but the women persist with their claims; seven years later, a private investigation leads to a surprising discovery.

Old-fashioned police work and computer animation determine how a 15-year-old boy was shot while inside a Dallas gun club.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.

Investigators use blood evidence to convict a man of murdering his wife.