
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

While at a real estate conference in St. Louis, a man finds his wife drowned in the bathtub in their hotel room.

Investigators piece together evidence found at the scene of a Native American woman's murder; the tire tracks and shoe impressions could lead them to the killer.

Experts seek answers to a young businesswoman's death just before she was to testify in a criminal trial.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.