
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

A murder mystery theater performance in Easton, Md., turns into a real-life mystery when a body is found after the performance ends.

When prison guard Donna Payant's body is discovered at a landfill, a medical examiner uses a "signature" clue to link her death to a murder the same examiner investigated 10 years earlier.

Police use DNA profiles of seed pods from a truck to catch a killer.