
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A quiet waitress who hasn't been to work in two days vanishes without a trace; police suspect a date gone wrong.

Fingerprints taken from a piece of cloth help solve the rape and murder of a 22-year-old woman in Henrico County, Va.

Fifteen years later, DNA technology leads to justice for a murdered woman and her savagely beaten 4-year-old daughter.

The FBI profiles a suspect in the kidnapping and murder of a 6-year-old girl during an evening church service; a witness leads authorities to the likely killer, but then becomes a victim herself.