
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Police link a clump of hair discovered in an isolated area with a woman who disappeared 20 years ago.

A news anchor is shot to death outside her home in an apparent crime of passion by a fan; a police dog tracks the scent of the killer back to the crime scene.

A trio of men, responsible for several bank robberies, leaves no evidence behind; forensic scientists help catch them by looking at the criminals' posture and clothing.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.