
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A serial arsonist was on the loose in Washington, DC. Each of the fires was started with the same type of incendiary device. The perpetrator was very careful, and seemed to leave no evidence behind... but there were clues in the ashes, and it was up to forensic scientists to find them.
A patrol officer is shocked by the amount of blood at a traffic accident and is shocked by the coroner's ruling until an anonymous phone call re-ignites the case.
An irrigation canal murder remains unsolved until a similar murder occurs.
A Russian immigrant is found dead and a strange phone call to his office is the only lead investigators have.