
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

On Valentine's Day, an obstetrician finds his wife dead and calls 911; police discover inconsistencies between the blood spatter evidence and his version of events.

In 1971, John List disappears after murdering his mother, wife and three children; he eludes the law for years until an age-scaled sculpture of the suspect and a true-crime TV program helps lead to his arrest in 1989.

Weed analysis and photogrammetry are used to help solve the 1995 murder of a California teenager is found dead after disappearing from her home.

Following an outbreak of thyrotoxicosis in Sioux Falls, S.D., thought to have come from contaminated meat, the Department of Agriculture conducts a review of the use of thyroid hormones in animal products.