
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

Raj faces deportation if he does not find a job; Leonard and Penny deal with Howard as a third wheel.

When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to win over Nobel laureates Kip Thorne, George Smoot and Frances Arnold; Halley's fear of the dark leads to opportunity and conflict.

Sheldon and Amy are thrilled when their super asymmetry theory is proven by two physicists, until they try to kick Amy off the Nobel nomination; Bernadette has a big success at work.

The gang heads to Stuart's comic book store to celebrate Halloween; Leonard uses science to seduce Penny.