
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
Leonard and the boys avoid Sheldon when he gets sick, leaving Penny to nurse him back to health.
Sheldon and Leonard look for a way to derail a 15-year-old physics prodigy's research.
When Sheldon tries to prove his mental superiority as they train for the Physics Bowl, the guys kick him off the team and bring his nemesis (Sara Gilbert) aboard.
Knowledge of Howard's sexual history makes Bernadette reconsider their future together.