
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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When Sheldon searches for an alternative to human companionship, the guys become concerned.
An embarrassing secret of Wolowitz's is revealed; Raj and Sheldon get into a war at work.
Leonard realizes he is the only one in his group without a girlfriend; Sheldon wants to get rid of his girlfriend.
Leonard keeps an affair a secret from Sheldon, Howard and Raj.