
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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The gang runs into Penny's old boyfriend while out at a wine bar; Bernadette spends an evening with Sheldon; Koothrappali's introduction of his new girlfriend doesn't go as planned.
Sheldon wants to go to a movie screening, so he pays Stuart to spend the day with Amy; Penny has a difficult time connecting with Leonard's visiting mother.
Leonard's recently divorced parents and Sheldon's devoutly religious mother visit; when they are contacted about their guidance system, Wolowitz and Koothrappali think the government is after them.
The group struggles through an awkward morning after Sheldon's mother and Leonard's father spend an evening together; Penny's family arrives.