
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is left in charge of the kids; Sheldon finds a book about experimenting on kids.

Sheldon and Leonard must defend themselves from an online bully's criticism after they co-publish a paper; Bernadette, Penny and Amy confront embarrassing moments during a girls night.

Howard and Raj hit a Goth nightclub to meet women; Sheldon tries chocolate-based behavior modification on Penny.

While the gang waits for the reopening of Stuart's comic book store Wolowitz gets some shocking news; Penny has trouble taking her own advice; Leonard and Raj think they spot Nathan Fillion at a restaurant.