
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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A flat tire during Leonard's bachelor party weekend in Mexico tests the guys' skills; Penny is compelled to tell her family that she and Leonard eloped.
An impending change to his living arrangements inspires Sheldon to revert to 2003, before he met Penny and Leonard; Raj and Howard form a band.
Barry Kripke expresses interest in Amy while leading a fencing lesson for the guys; when Stuart tries to attract female customers to the store, Penny, Amy and Bernadette help out.
Leonard and Sheldon go to great lengths to secure the helium they need during a nation-wide shortage; Bernadette and Penny try to find Amy a new man on a dating app.