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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
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S11, EP5 "The Collaboration Contamination"
Sheldon and Koothrappali confide in Bernadette when they can't handle Amy and Wolowitz working together; Penny and Leonard learn a secret from an unlikely source about dealing with Sheldon.
S1, EP6 "The Middle Earth Paradigm"
Leonard, Sheldon, Wolowitz and Koothrappali attend Penny's Halloween party.
S6, EP13 "The Bakersfield Expedition"
As the guys don costumes and go on a road trip to a comic book convention, the ladies decide to stay home and try to interpret a comic book.
S2, EP8 "The Lizard-Spock Expansion"
Leonard inadvertently steals away the new woman Wolowitz thinks is the love of his life.
