
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Bernadette tries to negotiate peace between Sheldon and Wolowitz; Penny receives an embarrassing offer; Raj wants Amy to write to a woman on his behalf.
Sheldon is faced with a new reality when he visits his mom in Houston; a murder mystery party starts arguments.
Raj struggles with guilt when he dates two women at once; Penny has a chance to play a part in a cheesy movie; Sheldon is torn between two gaming systems.
Sheldon has a personal crisis when he decides string theory is a waste of his time; a double date ends in embarrassment for Howard.