
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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During their weekend in Las Vegas, Bernadette and Amy accuse Penny of being a buzz kill; the guys try to invent the next big thing.
Raj and Sheldon try to simulate a dark-matter research expedition; after a fight about money, Penny and Leonard turn to Bernadette and Wolowitz for advice.
The guys try to help when Penny is faced with an awkward dilemma at work; Bernadette and Amy discuss sexuality and female scientists.
Sheldon feels pressured to participate in romantic traditions when the gang re-creates a high-school prom on the roof.