
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Sheldon tries to intervene when he learns that Penny is thinking about breaking up with Leonard; Howard is picked on in space by the other astronauts.
Amy feels threatened by Sheldon's new assistant; Wolowitz starts to feel the pressures of being in space.
Wolowitz's return from space isn't all he expected; game night becomes a gender war.
The gang heads to Stuart's comic book store to celebrate Halloween; Leonard uses science to seduce Penny.