
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Sheldon's latest scientific breakthrough leaves him feeling like a fraud; a romantic gesture between Howard and Bernadette causes Penny to up her game with Leonard.
When Professor Proton asks Leonard for help with an experiment, Sheldon retaliates by befriending Proton's rival, Bill Nye.
When a mistake comes to light, Sheldon makes Leonard walk a mile in his shoes; Penny decides to confront Raj's ex.
Amy and Leonard try to help Sheldon deal with his shame; Raj stays with Bernadette and Howard for a week.