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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S1, EP5 "The Hamburger Postulate"
Leonard, realizing his pursuit of Penny is fruitless, has an unexpected encounter with a fellow scientist (Sara Gilbert).
S1, EP6 "The Middle Earth Paradigm"
Leonard, Sheldon, Wolowitz and Koothrappali attend Penny's Halloween party.
S7, EP6 "The Romance Resonance"
Sheldon's latest scientific breakthrough leaves him feeling like a fraud; a romantic gesture between Howard and Bernadette causes Penny to up her game with Leonard.
S7, EP7 "The Proton Displacement"
When Professor Proton asks Leonard for help with an experiment, Sheldon retaliates by befriending Proton's rival, Bill Nye.
S12, EP24 "The Stockholm Syndrome"
Bernadette and Wolowitz leave their kids for the first time; Penny and Leonard try to keep a secret; Sheldon and Amy stick together; Koothrappali makes a new friend; the gang travels together into an uncharted future.
S12, EP23 "The Change Constant"
Sheldon and Amy await big news.