
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Leonard agrees to meet with a psychiatrist (Jane Kaczmarek) on Penny's behalf; Sheldon and Koothrappali work together on an astronomical discovery; Wolowitz and Bernadette struggle with their feelings when Stuart moves out.
After dealing with Sheldon while he was sick, Leonard, Penny and the gang attempt to treat themselves to a Sheldon-free weekend.
Sheldon's excitement about his Meemaw's visit fades when she butts heads with Amy; Raj questions his relationship with Emily after meeting someone new.
Amy and Sheldon host a Valentine's Day edition of Fun With Flags; Penny and Leonard wrestle with getting older; Howard and Bernadette make a discovery in their hot tub; Raj is torn between Emily and another woman.