
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Leonard inadvertently steals away the new woman Wolowitz thinks is the love of his life.
Sheldon tries to teach the guys a lesson after they cut him out of a potentially valuable investment; a seven-year-old video reveals a secret about Leonard and Penny's relationship.
Leonard and Sheldon try to avoid seeing Penny perform after hearing her sing, but the elaborate lie Sheldon tells leads to an unexpected result.
During their weekend in Las Vegas, Bernadette and Amy accuse Penny of being a buzz kill; the guys try to invent the next big thing.