
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Penny gets the opportunity to host Bill Gates at work when his company wants to partner with hers; Leonard, Koothrappali and Wolowitz do everything in their power to meet him; Sheldon thinks he is the victim of a prank.
After seeing Penny with a handsome new guy, Leonard rushes into a rebound relationship with Sheldon's nemesis, Leslie Winkle.
Leonard is less than thrilled when Penny considers accepting a job offer from Zack, her ex-boyfriend.
After celebrating the completion of the top-secret Air Force project, Leonard, Sheldon and Wolowitz get an unwelcome surprise; Amy receives an offer for a summer position as a visiting researcher.