
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is left in charge of the kids; Sheldon finds a book about experimenting on kids.

Unhappy to learn that Penny is seeing someone, Leonard summons the courage to ask another woman on a date.

Koothrappali is worried people won't take him seriously in his own field after publishing a paper that suggests he may have discovered alien life; Leonard wants to be the principal investigator on a plasma physics study.

Leonard volunteers to sign for a package, hoping to make a good impression on Penny.