
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

When Wolowitz dresses up as Sheldon for Halloween, Sheldon seeks retaliation at Leonard and Penny's Halloween party; Leonard is shocked when Penny doesn't remember their first kiss.

Leonard is caught between a rock and a hard place when he becomes responsible for distributing extra grant money; Bernadette turns the backyard playhouse into a hideaway to get away from her husband and kids.

Sheldon tries to bond with Amy's father, but when Wolowitz lures Mr. Fowler away with magic tricks, Sheldon has no choice but to bond with Mrs. Fowler; Koothrappali and Anu try to get physical for the first time.

Sheldon and Amy are devastated after learning from a Russian paper that Super Asymmetry has already been discovered and disproved; Bernadette wants to beat Howard in a popular video game.