
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

When Penny and Bernadette go to San Diego for a pharmaceutical sales convention, Wolowitz is left in charge of the kids; Sheldon finds a book about experimenting on kids.

Penny's ex-boyfriend Zack learns that he is infertile, so he asks Leonard for help; Koothrappali attempts to mend things with his ex-fiancee Anu.

Howard and Raj hit a Goth nightclub to meet women; Sheldon tries chocolate-based behavior modification on Penny.

When competitors Pemberton and Campbell charm America on a publicity tour, Sheldon and Amy try to win over Nobel laureates Kip Thorne, George Smoot and Frances Arnold; Halley's fear of the dark leads to opportunity and conflict.