
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Sheldon tests an MIT invention after hearing it can help him read people's emotions; Leonard finds out Penny's brother is coming to town; Raj asks his ex-girlfriends to give him dating advice.
Leonard and Wolowitz try to distract Sheldon when he slows the progress of their guidance system; Raj and Stuart look after baby Halley while Penny and Amy take Bernadette for a night out.
Sheldon and Amy have their first fight since moving in together; Koothrappali is shocked at the realities of financial independence when he stops receiving support from his father.
Cut off from his father's fortune, Koothrappali appoints Sheldon to help him get out of debt; Penny considers joining Leonard at Comic-Con.