
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

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Sheldon and Amy try to use math to eliminate wedding planning stress; Koothrappali "breaks up" with Wolowitz after realizing he is hurting his confidence.

Sheldon plans an authentic "Little House on the Prairie" dinner for Amy's birthday; Leonard receives a Christmas letter from his brother.

Sheldon and Amy subject their friends to a series of secret experiments to discover which two would be most qualified to be the best man and the maid of honor at their wedding; Penny reveals her true feelings about Amy.

Sheldon kicks Amy out to work solo; Amy and Leonard bond during a series of science experiments; Bert replaces Wolowitz in the band; Sheldon finds Penny a surprising source of scientific inspiration.