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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S4, EP24 "The Roommate Transmogrification"
Bernadette gets her Ph.D., inspiring the guys to tease Wolowitz about his lack of a doctorate; Raj becomes Sheldon's roommate.
S5, EP1 "The Skank Reflex Analysis"
Penny worries that she has ruined her relationship with her friends; Sheldon takes over the paintball team.
S5, EP2 "The Infestation Hypothesis"
Amy is caught in the middle when Penny and Sheldon get into an argument over a pre-owned chair; Leonard tries to make his long-distance relationship more exciting.
S4, EP12 "The Bus Pants Utilization"
Leonard's idea for a smartphone application causes friction in his friendship with Sheldon.
S4, EP23 "The Engagement Reaction"
Howard's mom winds up in the hospital after hearing news of her son's engagement to Bernadette.
S4, EP22 "The Wildebeest Implementation"
Raj tries to cure his social anxiety; Penny spies on Leonard and his girlfriend through Bernadette.
S4, EP21 "The Agreement Dissection"
Priya dissects the roommate agreement; the ladies take Sheldon dancing.
S4, EP20 "The Herb Garden Germination"
Amy and Sheldon spread gossip as part of an experiment; Howard decides to take a big step in his relationship with Bernadette.
