
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

After being humiliated on the radio, Sheldon vows to destroy Kripke; Wolowitz tries not to ruin his new relationship with Bernadette.

Sheldon tries to help Penny understand Leonard's work; Wolowitz gets jealous when Leonard starts hanging out with his new girlfriend.

Leonard is horrified when his mother (Christine Baranski) visits.

Howard's mom winds up in the hospital after hearing news of her son's engagement to Bernadette.