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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S9, EP8 "The Mystery Date Observation"
Sheldon, Wolowitz and Koothrappali post an ad online to find a new girlfriend for Sheldon; Penny and Bernadette decide to spy when Amy is secretive about who she is dating.
S6, EP10 "The Fish Guts Displacement"
When Amy gets sick, Sheldon tries to nurse her back to health; Wolowitz and his father-in-law plan a fishing trip.
S2, EP22 "The Classified Materials Turbulence"
Penny makes a surprising revelation about Leonard while on her date with Stuart; Wolowitz finds a critical design flaw in his NASA project.
S3, EP11 "The Maternal Congruence"
Leonard is horrified when his mother (Christine Baranski) visits.
S10, EP7 "The Veracity Elasticity"
Amy lies about repairs being made to her apartment so she can continue living with Sheldon; Leonard lets Penny decorate Sheldon's old room.
S10, EP6 "The Fetal Kick Catalyst"
Penny learns there are fans of her performance in "Serial Ape-ist" when she and Leonard attend a Comic Con event; Amy hosts a brunch at Penny's apartment; Wolowitz makes an impulsive purchase.
S10, EP5 "The Hot Tub Contamination"
Things do not run smoothly when Amy moves in with Sheldon, and Leonard and Penny have to intervene; Howard and Bernadette find unexpected guests at their house when they decide to cancel their vacation plans.
S10, EP4 "The Cohabitation Experimentation"
After her apartment floods, Amy suggests that she and Sheldon move in together; Koothrappali finds out the gender of Howard and Bernadette's baby before they do.
