
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

The weight of winning a Nobel Prize weighs heavy on Amy's shoulders; Koothrappali and Wolowitz try to relive the good old days after Wolowitz buys a scooter that looks like the one he had years ago.

Sheldon seeks revenge on his nemesis, Wil Wheaton; Wolowitz wants Penny to set him up with one of her friends.

Raj faces his loneliness when his friends are out on dates; while in space, Wolowitz gets drawn into a fight between Bernadette and his mom.

Sheldon tries to intervene when he learns that Penny is thinking about breaking up with Leonard; Howard is picked on in space by the other astronauts.