
Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?

Unhappy to learn that Penny is seeing someone, Leonard summons the courage to ask another woman on a date.

Leonard starts to reconsider his friendship with Sheldon; Wolowitz tries to choose his astronaut nickname.

Sheldon goes to work with Amy in her neurobiology lab when the university forces him to take a vacation; Bernadette asks Howard to sign a prenup.

Sheldon and his nemesis, Kripke, compete for a corner office; Penny feels uncomfortable after receiving a gift from Amy.