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Mensa-fied best friends and roommates Leonard and Sheldon, physicists who work at the California Institute of Technology, may be able to tell everybody more than they want to know about quantum physics, but getting through most basic social situations, especially ones involving women, totally baffles them. How lucky, then, that babe-alicious waitress/aspiring actress Penny moves in next door. Frequently seen hanging out with Leonard and Sheldon are friends and fellow Caltech scientists Wolowitz and Koothrappali. Will worlds collide? Does Einstein theorize in the woods?
S1, EP17 "The Tangerine Factor"
When Leonard finally works up the courage to ask Penny out on a date, they each turn to Sheldon for advice.
S2, EP1 "The Bad Fish Paradigm"
Penny's first date with Leonard goes awry; Penny finds Sheldon to be an unwilling confidant.
S2, EP2 "The Codpiece Topology"
After seeing Penny with a handsome new guy, Leonard rushes into a rebound relationship with Sheldon's nemesis, Leslie Winkle.
S5, EP6 "The Rhinitis Revelation"
Sheldon finds himself competing with the gang for his mother's (Laurie Metcalf) attention when she visits.
S11, EP6 "The Proton Regeneration"
Sheldon auditions for the role of the new Professor Proton; Penny takes care of Halley when Bernadette and Wolowitz need bed rest.
S11, EP5 "The Collaboration Contamination"
Sheldon and Koothrappali confide in Bernadette when they can't handle Amy and Wolowitz working together; Penny and Leonard learn a secret from an unlikely source about dealing with Sheldon.
S11, EP4 "The Explosion Implosion"
Wolowitz and Sheldon bond over having disappointing fathers; Leonard is disturbed when his mother finds a new best friend in Penny.
S11, EP3 "The Relaxation Integration"
As Sheldon stresses about picking a wedding date, Amy tries to convince him he has a more laid-back side; Koothrappali and Stuart compete to win the heart of Bernadette's new co-worker.
