
This animated series features the adventures of the Griffin family. Endearingly ignorant Peter and his stay-at-home wife, Lois, reside in Quahog, R.I., and have three kids. Meg, the eldest child, is a social outcast, and teenage Chris is awkward and clueless when it comes to the opposite sex. The youngest, Stewie, is a genius baby who is bent on killing his mother and destroying the world. Brian, the talking dog, keeps Stewie in check while sipping martinis and sorting through his own issues.

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Brian meets and falls in love with Jess, who reveals she has cancer; after she receives devastating news regarding her diagnosis, Brian proposes marriage to her.
Brian's marriage to Jess is not what he envisioned; at Peter's suggestion, Brian lets himself go, causing Jess to make a surprising decision.
After Brian teases Stewie for being small, Stewie invents a shrinking machine that results in both of them shrinking to a microscopic size.
Lois receives a surprising birthday present from her father, which leads to an unfortunate accident that leaves him dependent on Lois and the Griffins' care.