
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

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The team investigates when a TV producer is murdered; Christine is accused of biting a classmate; Hodgins uses his tools at the Jeffersonian to chemically re-create Finn's hot sauce.
The team investigates when a stockbroker -- who moonlights as a stripper -- is murdered; after a 24-year absence, Booth's mother (Joanna Cassidy) shows up with a request.
The team tries to prevent a viral outbreak during an investigation into a journalist's murder, whose infected body is found at a biohazard facility; when Arastoo Vaziri is affected by the mutated virus, the only way to save him is to solve the case.
Christopher Pelant returns to toy with the Jeffersonian team; an investigation reveals a string of murders tied to FBI agents; Brennan evaluates her relationship with Booth.