
Dr. Temperance Brennan, a forensic anthropologist who works at the Jeffersonian Institution and also writes books, has an impressive ability to read clues from victims' bones. Consequently, law enforcement calls her to assist with investigations when remains are so badly decomposed, burned or destroyed that standard identification methods are useless. Brennan is teamed with Special Agent Seeley Booth, a former Army sniper, who mistrusts science and scientists when it comes to solving crimes but who has developed respect for Brennan, both professionally and personally.

When Brennan officially returns to work at the Jeffersonian and Booth resumes his position at the FBI, remains are found at a fish farm; Hodgins encourages Angela to exhibit her photography work; Cam faces a difficult decision.

Brennan enlists the help of a fellow forensic anthropologist; investigating the death of a real estate agent whose remains appear to have been destroyed by coyote-wolf hybrids.

While investigating a case involving a headless corpse, Brennan and Booth encounter Ichabod Crane and Abbie Mills searching for answers of their own; Brennan and Booth come up with Halloween pranks.

Two sanitation workers (Sal Vulcano and James Murray) find a U.S. senator's corpse in a street sweeper; Aubrey looks into Jessica's past.